TY  - JOUR
A1  - Bowes, John
A1  - Budu-Aggrey, Ashley
A1  - Huffmeier, Ulrike
A1  - Uebe, Steffen
A1  - Steel, Kathryn
A1  - Hebert, Harry L.
A1  - Wallace, Chris
A1  - Massey, Jonathan
A1  - Bruce, Ian N.
A1  - Bluett, James
A1  - Feletar, Marie
A1  - Morgan, Ann W.
A1  - Marzo-Ortega, Helena
A1  - Donohoe, Gary
A1  - Morris, Derek W.
A1  - Helliwell, Philip
A1  - Ryan, Anthony W.
A1  - Kane, David
A1  - Warren, Richard B.
A1  - Korendowych, Eleanor
A1  - Alenius, Gerd-Marie
A1  - Giardina, Emiliano
A1  - Packham, Jonathan
A1  - McManus, Ross
A1  - FitzGerald, Oliver
A1  - McHugh, Neil
A1  - Brown, Matthew A.
A1  - Ho, Pauline
A1  - Behrens, Frank
A1  - Burkhardt, Harald
A1  - Reis, Andre
A1  - Barton, Anne
T1  - Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
T2  - Nature Communications
N2  - Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39383
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-393833
SN  - 2041-1723
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
VL  - 6
IS  - 6046
SP  - 1
EP  - 10
PB  - Nature Publishing Group
CY  - London
ER  -