TY  - JOUR
A1  - Knöchel, Christian
A1  - Voß, Martin
A1  - Grüter, Florian
A1  - Alves, Gilberto Sousa
A1  - Matura, Silke
A1  - Sepanski, Beate
A1  - Stäblein, Michael
A1  - Wenzler, Sofia Maria
A1  - Prvulovic, David
A1  - Carvalho, André Férrer
A1  - Oertel-Knöchel, Viola
T1  - Omega 3 fatty acids: novel neurotherapeutic targets for cognitive dysfunction in mood disorders and schizophrenia?
T2  - Current neuropharmacology
N2  - An increasing body of evidences from preclinical as well as epidemiological and clinical studies suggest a potential beneficial role of dietary intake of omega-3 fatty acids for cognitive functioning. In this narrative review, we will summarize and discuss recent findings from epidemiological, interventional and experimental studies linking dietary consumption of omega-3 fatty acids to cognitive function in healthy adults. Furthermore, affective disorders and schizophrenia (SZ) are characterized by cognitive dysfunction encompassing several domains. Cognitive dysfunction is closely related to impaired functioning and quality of life across these conditions. Therefore, the current review focues on the potential influence of omega-3 fatty acids on cognition in SZ and affective disorders. In sum, current data predominantly from mechanistic models and animal studies suggest that adjunctive omega-3 fatty acid supplementation could lead to improved cognitive functioning in SZ and affective disorders. However, besides its translational promise, evidence for clinical benefits in humans has been mixed. Notwithstanding evidences indicate that adjunctive omega-3 fatty acids may have benefit for affective symptoms in both unipolar and bipolar depression, to date no randomized controlled trial had evaluated omega-3 as cognitive enhancer for mood disorders, while a single published controlled trial suggested no therapeutic benefit for cognitive improvement in SZ. Considering the pleiotropic mechanisms of action of omega-3 fatty acids, the design of well-designed controlled trials of omega-3 supplementation as a novel, domain-specific, target for cognitive impairment in SZ and affective disorders is warranted.
KW  - bipolar disorder
KW  - cognition
KW  - depression
KW  - omega-3 fatty acids
KW  - psychosis
KW  - schizophrenia
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41291
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-412918
SN  - 1570-159X
N1  - Copyright ©2015 Bentham Science Publishers This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
VL  - 13
SP  - 663
EP  - 680
PB  - Bentham Science Publishers
ER  -