TY  - JOUR
A1  - Tobias, Nicholas J.
A1  - Mishra, Bagdevi
A1  - Gupta, Deepak Kumar
A1  - Sharma, Rahul
A1  - Thines, Marco
A1  - Stinear, Timothy P.
A1  - Bode, Helge Björn
T1  - Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle
T2  - BMC genomics
N2  - Background: Bacteria within the genus Photorhabdus maintain mutualistic symbioses with nematodes in complicated lifecycles that also involves insect pathogenic phases. Intriguingly, these bacteria are rich in biosynthetic gene clusters that produce compounds with diverse biological activities. As a basis to better understand the life cycles of Photorhabdus we sequenced the genomes of two recently discovered representative species and performed detailed genomic comparisons with five publically available genomes.
Results: Here we report the genomic details of two new reference Photorhabdus species. By then conducting genomic comparisons across the genus, we show that there are several highly conserved biosynthetic gene clusters. These clusters produce a range of bioactive small molecules that support the pathogenic phase of the integral relationship that Photorhabdus maintain with nematodes.
Conclusions: Photorhabdus contain several genetic loci that allow them to become specialist insect pathogens by efficiently evading insect immune responses and killing the insect host.
KW  - Photorhabdus
KW  - Sequencing
KW  - Secondary metabolites
KW  - Symbiosis
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42221
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-422213
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971723
UR  - http://link.springer.com/article/10.1186/s12864-016-2862-4
SN  - 1471-2164
N1  - © 2016 The Author(s). Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
VL  - 17
IS  - 537
SP  - 1
EP  - 11
PB  - BioMed Central ; Springer
CY  - London ; Berlin ; Heidelberg
ER  -