TY  - JOUR
A1  - Bionda, Tihana
A1  - Behrends, Christian
T1  - Unveiling ubiquitinome rearrangements induced by salmonella infection
T2  - Autophagy
N2  - Ubiquitination plays a critical role in the activation of host immune responses to infection and serves as a signal for pathogen delivery to phagophores along the xenophagy pathway. We recently performed systematic ubiquitination site profiling of epithelial cells infected with Salmonella Typhimurium. Our findings specifically highlight components of the NFKB, membrane trafficking pathways and RHO GTPase systems as ubiquitination hubs during infection. In addition, a broad spectrum of bacterial effectors and several outer membrane proteins are ubiquitinated in infected cells. This comprehensive resource of ubiquitinome dynamics during Salmonella infection enables further understanding of the complex host-pathogen interplay and may reveal novel targets for the inhibition of Salmonella invasion and inflammation.
KW  - immune response
KW  - Salmonella infection
KW  - ubiquitin coat
KW  - ubiquitination
KW  - xenophagy
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42262
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-422627
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082772
SN  - 1554-8627
SN  - 1554-8635
N1  - © 2016 Tihana Bionda and Christian Behrends. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
VL  - 12
IS  - 9
SP  - 1683
EP  - 1684
PB  - Taylor & Francis
CY  - Abingdon, Oxon
ER  -