TY  - JOUR
A1  - Hofmann, Matthias
A1  - Pflanzer, Ralph
A1  - Habib, Anowarul
A1  - Shelke, Amit
A1  - Bereiter-Hahn, Jürgen
A1  - Bernd, August
A1  - Kaufmann, Roland
A1  - Sader, Robert Alexander
A1  - Kippenberger, Stefan
T1  - Scanning acoustic microscopy : a novel noninvasive method to determine tumor interstitial fluid pressure in a xenograft tumor model
T2  - Translational oncology
N2  - Elevated tumor interstitial fluid pressure (TIFP) is a prominent feature of solid tumors and hampers the transmigration of therapeutic macromolecules, for example, large monoclonal antibodies, from tumor-supplying vessels into the tumor interstitium. TIFP values of up to 40 mm Hg have been measured in experimental solid tumors using two conventional invasive techniques: the wick-in-needle and the micropuncture technique. We propose a novel noninvasive method of determining TIFP via ultrasonic investigation with scanning acoustic microscopy at 30-MHz frequency. In our experimental setup, we observed for the impedance fluctuations in the outer tumor hull of A431-vulva carcinoma–derived tumor xenograft mice. The gain dependence of signal strength was quantified, and the relaxation of tissue was calibrated with simultaneous hydrostatic pressure measurements. Signal patterns from the acoustical images were translated into TIFP curves, and a putative saturation effect was found for tumor pressures larger than 3 mm Hg. This is the first noninvasive approach to determine TIFP values in tumors. This technique can provide a potentially promising noninvasive assessment of TIFP and, therefore, can be used to determine the TIFP before treatment approach as well to measure therapeutic efficacy highlighted by lowered TFP values.
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42275
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-422759
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856858
UR  - http://www.transonc.com/article/S1936-5233(15)30078-4/abstract
SN  - 1936-5233
SN  - 1944-7124
N1  - © 2016 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 9
IS  - 3
SP  - 179
EP  - 183
PB  - [s. n.]
CY  - Ann Arbor, Mich.
ER  -