TY  - JOUR
A1  - Gani, Cihan
A1  - Bonomo, Pierluigi
A1  - Zwirner, Kerstin
A1  - Schroeder, Christopher
A1  - Menegakis, Apostolos
A1  - Rödel, Claus
A1  - Zips, Daniel
T1  - Organ preservation in rectal cancer – challenges and future strategies
T2  - Clinical and translational radiation oncology
N2  - Neoadjuvant radiochemotherapy with subsequent total mesorectal excision is the standard of care for locally advanced rectal cancer. While this multimodal strategy has decreased local recurrences rates below 5%, long-term morbidities are considerable in terms of urinary, sexual or bowel functioning. At the same time approximately 10–20% of patients have no evidence of residual tumour in their surgical specimen. Pioneering studies from Brazil have suggested that surgery can safely be omitted in carefully selected patients with a clinical complete response after radiochemotherapy. Although confirmatory studies showed similar results, challenges in terms of optimizing radiochemotherapy for organ-preservation, appropriate selection of patients for non-operative management and the safety of this approach remain. The present review will summarize the current data on organ-preservation in rectal cancer and discuss the challenges that need to be addressed in future trials.
KW  - Rectal cancer
KW  - Wait and see
KW  - Organ preservation
KW  - Radiochemotherapy
KW  - Radiotherapy
KW  - Chemoradiotherapy
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46335
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-463355
SN  - 2405-6308
N1  - © 2017 The Authors. Published by Elsevier Ireland Ltd on behalf of European Society for Radiotherapy and Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 3
SP  - 9
EP  - 15
PB  - Elsevier
CY  - Amsterdam
ER  -