TY  - JOUR
A1  - Weiser, Christian
A1  - Petkova, Mina
A1  - Rengstl, Benjamin
A1  - Döring, Claudia
A1  - Laer, Dorothee von
A1  - Hartmann, Sylvia
A1  - Küppers, Ralf
A1  - Hansmann, Martin-Leo
A1  - Newrzela, Sebastian
T1  - Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model
T2  - OncoTarget
N2  - The mechanisms involved in malignant transformation of mature B and T lymphocytes are still poorly understood. In a previous study, we compared gene expression profiles of the tumor cells of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) to their normal cellular counterparts and found the basic leucine zipper protein ATF-like 3 (BATF3) to be significantly upregulated in the tumor cells of both entities. To assess the oncogenic potential of BATF3 in lymphomagenesis and to dissect the molecular interactions of BATF3 in lymphoma cells, we retrovirally transduced murine mature T and B cells with a BATF3-encoding viral vector and transplanted each population into Rag1-deficient recipients. Intriguingly, BATF3-expressing B lymphocytes readily induced B-cell lymphomas after characteristic latencies, whereas T-cell transplanted animals remained healthy throughout the observation time. Further analyses revealed a germinal center B-cell-like phenotype of most BATF3-initiated lymphomas. In a multiple myeloma cell line, BATF3 inhibited BLIMP1 expression, potentially illuminating an oncogenic action of BATF3 in B-cell lymphomagenesis. In conclusion, BATF3 overexpression induces malignant transformation of mature B cells and might serve as a potential target in B-cell lymphoma treatment.
KW  - BATF3
KW  - B-cell immunology
KW  - B-cell lymphoma
KW  - germinal center
KW  - oncogene
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46343
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-463436
SN  - 1949-2553
N1  - Copyright: Weiser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - 22
SP  - 15942
EP  - 15951
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -