TY  - JOUR
A1  - Olesch, Catherine
A1  - Ringel, Christian
A1  - Brüne, Bernhard
A1  - Weigert, Andreas
T1  - Beyond immune cell migration : the emerging role of the sphingosine-1-phosphate receptor S1PR4 as a modulator of innate immune cell activation
T2  - Mediators of inflammation
N2  - The sphingolipid sphingosine-1-phosphate (S1P) emerges as an important regulator of immunity, mainly by signaling through a family of five specific G protein-coupled receptors (S1PR1–5). While S1P signaling generally has the potential to affect not only trafficking but also differentiation, activation, and survival of a diverse range of immune cells, the specific outcome depends on the S1P receptor repertoire expressed on a given cell. Among the S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the S1P/S1PR4 axis in immunity. Recent studies indeed highlight its role in activation of immune cells, differentiation, and, potentially, trafficking. In this review, we summarize the emerging data that support a major role of S1PR4 in modulating immunity in humans and mice and discuss therapeutic implications.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46370
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-463702
SN  - 1466-1861
SN  - 0962-9351
N1  - Copyright © 2017 Catherine Olesch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 26
IS  - Art. 6059203
SP  - 1
EP  - 12
PB  - Hindawi Publishing Corp.
CY  - Sylvania, Ohio
ER  -