TY  - JOUR
A1  - Prall, Matthias
A1  - Durante, Marco
A1  - Berger, Thomas
A1  - Przybyla, Bartos
A1  - Graef, Christian
A1  - Lang, Philipp-M.
A1  - LaTessa, Chiara
A1  - Shestov, Lev
A1  - Simoniello, Palma
A1  - Danly, Chris R.
A1  - Mariam, Fesseha G.
A1  - Merrill, Frank Edward
A1  - Nedrow, Paul
A1  - Wilde, Carl
A1  - Varentsov, Dmitry
T1  - High-energy proton imaging for biomedical applications
T2  - Scientific reports
N2  - The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.
KW  - Biomedical engineering
KW  - Preclinical research
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46546
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-465463
SN  - 2045-2322
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
VL  - 6
IS  - Art. 27651
SP  - 1
EP  - 11
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -