TY  - JOUR
A1  - Bothou, Christina
A1  - Alexopoulos, Alexis
A1  - Dermitzaki, Eleni
A1  - Kleanthous, Kleanthis
A1  - Papadimitriou, Anastasios
A1  - Mastorakos, George
A1  - Papadimitriou, Dimitrios
T1  - Successful treatment of severe atopic dermatitis with calcitriol and paricalcitol in an 8-year-old girl
T2  - Case reports in pediatrics
N2  - Atopic dermatitis (AD) is a chronic inflammatory disease affecting children and adolescence. The traditional therapeutic options for AD, including emollients topically and immune modulatory agents systemically focusing on reducing skin inflammation and restoring the function of the epidermal barrier, are proven ineffective in many cases. Several studies have linked vitamin D supplementation with either a decreased risk to develop AD or a clinical improvement of the symptoms of AD patients. In this report, we present a girl with severe AD who under adequate supplementation with cholecalciferol was treated with calcitriol and subsequently with paricalcitol. She had significant improvement—almost healing of her skin lesions within 2 months, a result sustained for more than 3 years now. Because of hypercalciuria as a side effect from calcitriol therapy, treatment was continued with paricalcitol, a vitamin D analogue used in secondary hyperparathyroidism in chronic kidney disease. Calcitriol therapy may be considered as a safe and efficacious treatment option for patients with severe AD, particularly for those with refractory AD, under monitoring for possible side effects. Treatment with paricalcitol resolves hypercalciuria, is safe, and should be further investigated as an alternative treatment of atopic dermatitis and possibly other diseases of autoimmune origin.
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46593
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-465939
SN  - 2090-6811
SN  - 2090-6803
N1  - Copyright © 2018 Christina Bothou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2018
IS  - Art. 9643543
SP  - 1
EP  - 5
PB  - Hindawi
CY  - New York, NY
ER  -