TY - JOUR A1 - Brandes, Ralf A1 - Rezende Felipe, Flávia Figueiredo de A1 - Schröder, Katrin T1 - Redox regulation beyond ROS : why ROS should not be measured as often T2 - Circulation research N2 - Based on the concept of oxidative stress, reactive oxygen species (ROS) have been incriminated as the drivers behind almost every cardiovascular pathology. Redox alterations are, however, omnipresent bystanders to changes in cellular activity state. Even when ROS levels are altered, their contribution to pathology is not necessarily causal. Researchers should hesitate to engage in global ROS measurements and rather aim on identifying individual molecular targets of redox regulation. KW - reactive oxygen species KW - antioxidants KW - cytokines KW - cardiovascular diseases KW - oxygen Y1 - 2018 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47169 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-471697 SN - 1524-4571 SN - 0009-7330 N1 - © 2018 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. VL - 123 IS - 3 SP - 326 EP - 328 PB - Assoc. CY - New York, NY ER -