TY - JOUR A1 - Schellinger, Peter Dieter A1 - Tsivgoulis, Georgios A1 - Steiner, Thorsten A1 - Köhrmann, Martin T1 - Percutaneous left atrial appendage occlusion for the prevention of stroke in patients with atrial fibrillation : review and critical appraisal T2 - Journal of stroke N2 - The authors review the current status of percutaneous left atrial appendage (LAA) occlusion therapy in patients with atrial fibrillation with the goal to prevent ischemic stroke and systemic embolism and to reduce oral anticoagulation associated bleeding. While we cover the historical and also surgical background, and all tested devices, the main focus rests on the single currently U.S. Food and Drug Administration (FDA) approved LAA occluder, the WATCHMAN device, and its approval process. The authors also give a critical appraisal beyond the review of mere facts, trying to put the current data into perspective. KW - Atrial fibrillation KW - Stroke KW - Atrial appendage occlusion KW - Brain ischemia KW - Intracranial hemorrhage Y1 - 2018 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47705 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-477059 SN - 2287-6405 SN - 2287-6391 N1 - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. VL - 20 IS - 3 SP - 281 EP - 291 PB - Korean Stroke Society CY - Seoul ER -