TY  - JOUR
A1  - Danciu, Corina
A1  - Zupko, Istvan
A1  - Bor, Andrea
A1  - Schwiebs, Anja
A1  - Radeke, Heinfried H.
A1  - Hancianu, Monica
A1  - Cioanca, Oana
A1  - Alexa, Ersilia
A1  - Oprean, Camelia
A1  - Bojin, Florina
A1  - Soica, Codruta
A1  - Paunescu, Virgil
A1  - Dehelean, Cristina Adriana
T1  - Botanical therapeutics : phytochemical screening and biological assessment of chamomile, parsley and celery extracts against A375 human melanoma and dendritic cells
T2  - International journal of molecular sciences
N2  - Chamomile, parsley, and celery represent major botanical sources of apigenin, a well-known flavone with chemopreventive properties. The aim of this study was to assess the phytochemical composition, antioxidant, and anti-inflammatory potential of methanol extracts obtained from chamomile, parsley, and celery collected from Romania, as well as the biological activity against A375 human melanoma and human dendritic cells. Results have shown that all three extracts are rich in polyphenolic compounds and flavonoids, and they generate a radical scavenger capacity, iron chelation potential, as well as lipoxygenase inhibition capacity. Chamomile and celery extracts present weak antiproliferative and pro-apoptotic properties in the set experimental conditions, while parsley extract draws out significant pro-apoptotic potential against A375 human melanoma cells. Parsley and chamomile extracts affected the fibroblast-like morphology of the screened tumor cell line. On the other hand, chamomile and celery extracts abrogated the expansion of LPS-activated dendritic cells, while the metabolic activity was attenuated by stimulation with celery extract; chamomile and parsley extracts had no effect upon this parameter. Chamomile and parsley extracts incubation with naive dendritic cells did not trigger cytokine secretion (TNF-alpha, IL-6, IL-10), but celery extract stimulation significantly reduced the anti-inflammatory, cytokine IL-10.
KW  - chamomile
KW  - parsley
KW  - celery
KW  - antioxidant
KW  - anti-inflammatory
KW  - A375 human melanoma cells
KW  - dendritic cells
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48488
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-484881
SN  - 1422-0067
SN  - 1661-6596
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
VL  - 19
IS  - 11, Art. 3624
SP  - 1
EP  - 20
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -