TY  - JOUR
A1  - Kovacic, Jason C.
A1  - Dimmeler, Stefanie
A1  - Harvey, Richard P.
A1  - Finkel, Toren
A1  - Aikawa, Elena
A1  - Krenning, Guido
A1  - Baker, Andrew H.
T1  - Endothelial to mesenchymal transition in cardiovascular disease : JACC state-of-the-art review
T2  - Journal of the American College of Cardiology
N2  - Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell undergoes a series of molecular events that lead to a change in phenotype toward a mesenchymal cell (e.g., myofibroblast, smooth muscle cell). EndMT plays a fundamental role during development, and mounting evidence indicates that EndMT is involved in adult cardiovascular diseases (CVDs), including atherosclerosis, pulmonary hypertension, valvular disease, and fibroelastosis. Therefore, the targeting of EndMT may hold therapeutic promise for treating CVD. However, the field faces a number of challenges, including the lack of a precise functional and molecular definition, a lack of understanding of the causative pathological role of EndMT in CVDs (versus being a “bystander-phenomenon”), and a lack of robust human data corroborating the extent and causality of EndMT in adult CVDs. Here, we review this emerging but exciting field, and propose a framework for its systematic advancement at the molecular and translational levels.
KW  - cardiovascular
KW  - EndMT
KW  - endothelial to mesenchymal transition
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47278
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-472782
SN  - 1558-3597
SN  - 0735-1097
N1  - © 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
VL  - 73
IS  - 2
SP  - 190
EP  - 209
PB  - Elsevier ; American College of Cardiology
CY  - New York, NY
ER  -