TY - JOUR A1 - Eisel, Bianca A1 - Hartrampf, Felix A1 - Meier, Thomas A1 - Trauner, Dirk T1 - Reversible optical control of F1Fo‐ATP synthase using photoswitchable inhibitors T2 - FEBS letters N2 - F1Fo‐ATP synthase is one of the best studied macromolecular machines in nature. It can be inhibited by a range of small molecules, which include the polyphenols, resveratrol and piceatannol. Here, we introduce Photoswitchable Inhibitors of ATP Synthase, termed PIAS, which were synthetically derived from these polyphenols. They can be used to reversibly control the enzymatic activity of purified yeast Yarrowia lipolyticaATP synthase by light. Our experiments indicate that the PIAS bind to the same site in the ATP synthase F1 complex as the polyphenols in their trans form, but they do not bind in their cis form. The PIAS could be useful tools for the optical precision control of ATP synthase in a variety of biochemical and biotechnological applications. KW - photopharmacology KW - Yarrowia lipolytica F1Fo-ATP synthase Y1 - 2018 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48611 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-486118 SN - 1873-3468 SN - 0014-5793 N1 - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. VL - 592 IS - 3 SP - 343 EP - 355 PB - Wiley CY - Chichester ER -