TY  - JOUR
A1  - Schaworonkow, Natalie
A1  - Gordon, Pedro Caldana
A1  - Belardinelli, Paolo
A1  - Ziemann, Ulf
A1  - Bergmann, Til Ole
A1  - Zrenner, Christoph
T1  - μ-Rhythm extracted with personalized EEG filters correlates with corticospinal excitability in real-time phase-triggered EEG-TMS
T2  - Frontiers in neuroscience
N2  - Ongoing brain activity has been implicated in the modulation of cortical excitability. The combination of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) in a real-time triggered setup is a novel method for testing hypotheses about the relationship between spontaneous neuronal oscillations, cortical excitability, and synaptic plasticity. For this method, a reliable real-time extraction of the neuronal signal of interest from scalp EEG with high signal-to-noise ratio (SNR) is of crucial importance. Here we compare individually tailored spatial filters as computed by spatial-spectral decomposition (SSD), which maximizes SNR in a frequency band of interest, against established local C3-centered Laplacian filters for the extraction of the sensorimotor μ-rhythm. Single-pulse TMS over the left primary motor cortex was synchronized with the surface positive or negative peak of the respective extracted signal, and motor evoked potentials (MEP) were recorded with electromyography (EMG) of a contralateral hand muscle. Both extraction methods led to a comparable degree of MEP amplitude modulation by phase of the sensorimotor μ-rhythm at the time of stimulation. This could be relevant for targeting other brain regions with no working benchmark such as the local C3-centered Laplacian filter, as sufficient SNR is an important prerequisite for reliable real-time single-trial detection of EEG features.
KW  - spatial filtering
KW  - brain-state-dependent stimulation
KW  - sensorimotor oscillations
KW  - EEG-TMS
KW  - corticospinal excitability
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48689
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-486890
SN  - 1662-453X
SN  - 1662-4548
N1  - Copyright © 2018 Schaworonkow, Caldana Gordon, Belardinelli, Ziemann, Bergmann and Zrenner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 12
IS  - Art. 954
SP  - 1
EP  - 6
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -