TY  - JOUR
A1  - Roeper, Jochen
T1  - Closing gaps in brain disease — from overlapping genetic architecture to common motifs of synapse dysfunction
T2  - Current opinion in neurobiology
N2  - Recent progress in the synaptic pathophysiology of brain diseases is reviewed. To emphasize the emergence of common motifs in synapse dysfunctions across neurodevelopmental, psychiatric and neurological disorders, conventional clinical boundaries are disregarded and a decidedly trans-diagnostic, potentially unifying view of altered synapse function is promoted. Based on the overlapping genetic architecture of brain disorders, which often converges on genes related to synaptic functions, disease-related changes in basic pre-synaptic and post-synaptic communication, neuromodulation-gated changes in Hebbian plasticity, dynamic interactions between Hebbian and homeostatic plasticity, and changes in synaptic maintenance by autophagy and glial-mediated phagocytosis are highlighted.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/49200
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-492003
SN  - 1873-6882
SN  - 0959-4388
N1  - © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
VL  - 48
SP  - 45
EP  - 51
PB  - Current Biology
CY  - Philadelphia, Pa.
ER  -