TY  - JOUR
A1  - Lérias, Joana
A1  - Paraschoudi, Georgia
A1  - Silva, Ines
A1  - Martins, João
A1  - Sousa, Eric de
A1  - Condeço, Carolina
A1  - Figueiredo, Nuno
A1  - Carvalho, Carlos
A1  - Dodoo, Ernest
A1  - Jäger, Elke
A1  - Rao, Martin
A1  - Maeurer, Markus
T1  - Clinically relevant immune responses against Cytomegalovirus : implications for precision medicine
T2  - International journal of molecular sciences
N2  - Immune responses to human cytomegalovirus (CMV) can be used to assess immune fitness in an individual. Further to its clinical significance in posttransplantation settings, emerging clinical and translational studies provide examples of immune correlates of protection pertaining to anti-CMV immune responses in the context of cancer or infectious diseases, e.g., tuberculosis. In this viewpoint, we provide a brief overview about CMV-directed immune reactivity and immune fitness in a clinical context and incorporate some of our own findings obtained from peripheral blood or tumour-infiltrating lymphocytes (TIL) from patients with advanced cancer. Observations in patients with solid cancers whose lesions contain both CMV and tumour antigen-specific T-cell subsets are highlighted, due to a possible CMV-associated "bystander" effect in amplifying local inflammation and subsequent tumour rejection. The role of tumour-associated antibodies recognising diverse CMV-derived epitopes is also discussed in light of anti-cancer immune responses. We discuss here the use of anti-CMV immune responses as a theranostic tool—combining immunodiagnostics with a personalised therapeutic potential—to improve treatment outcomes in oncological indications.
KW  - cytomegalovirus
KW  - immune responses
KW  - interferon gamma
KW  - antibodies
KW  - cancer
KW  - immunotherapy
KW  - T cells
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50125
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-501257
SN  - 1422-0067
SN  - 1661-6596
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
VL  - 20
IS  - 8, Art. 1986
SP  - 1
EP  - 13
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -