TY  - JOUR
A1  - Dvorak, Jannis
A1  - Hilke, Marietheres
A1  - Trettin, Marco
A1  - Wenzler, Sofia Maria
A1  - Hagen, Marleen
A1  - Ghirmai, Naddy
A1  - Müller, Maximilian
A1  - Kraft, Dominik
A1  - Reif, Andreas
A1  - Oertel-Knöchel, Viola
T1  - Aberrant brain network topology in fronto‐limbic circuitry differentiates euthymic bipolar disorder from recurrent major depressive disorder
T2  - Brain and behavior
N2  - Introduction: Previous studies have established graph theoretical analysis of functional network connectivity (FNC) as a potential tool to detect neurobiological underpinnings of psychiatric disorders. Despite the promising outcomes in studies that examined FNC aberrancies in bipolar disorder (BD) and major depressive disorder (MDD), there is still a lack of research comparing both mood disorders, especially in a nondepressed state. In this study, we used graph theoretical network analysis to compare brain network properties of euthymic BD, euthymic MDD and healthy controls (HC) to evaluate whether these groups showed distinct features in FNC.
Methods: We collected resting‐state functional magnetic resonance imaging (fMRI) data from 20 BD patients, 15 patients with recurrent MDD as well as 30 age‐ and gender‐matched HC. Graph theoretical analyses were then applied to investigate functional brain networks on a global and regional network level.
Results: Global network analysis revealed a significantly higher mean global clustering coefficient in BD compared to HC. We further detected frontal, temporal and subcortical nodes in emotion regulation areas such as the limbic system and associated regions exhibiting significant differences in network integration and segregation in BD compared to MDD patients and HC. Participants with MDD and HC only differed in frontal and insular network centrality.
Conclusion: In conclusion, our findings indicate that a significantly altered brain network topology in the limbic system might be a trait marker specific to BD. Brain network analysis in these regions may therefore be used to differentiate euthymic BD not only from HC but also from patients with MDD.
KW  - bipolar disorder
KW  - euthymic
KW  - fMRI
KW  - functional connectivity
KW  - graph theory
KW  - major depressive disorder
KW  - resting‐state
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50256
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-502569
SN  - 2162-3279
N1  - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
VL  - 2019
IS  - e01257
SP  - 1
EP  - 14
PB  - Wiley
CY  - Malden, Mass.
ER  -