TY  - JOUR
A1  - Jedlička, Peter
A1  - Muellerleile, Julia
A1  - Schwarzacher, Stephan
T1  - Synaptic plasticity and excitation-inhibition balance in the dentate gyrus : insights from in vivo recordings in neuroligin-1, neuroligin-2, and collybistin knockouts
T2  - Neural plasticity
N2  - The hippocampal dentate gyrus plays a role in spatial learning and memory and is thought to encode differences between similar environments. The integrity of excitatory and inhibitory transmission and a fine balance between them is essential for efficient processing of information. Therefore, identification and functional characterization of crucial molecular players at excitatory and inhibitory inputs is critical for understanding the dentate gyrus function. In this minireview, we discuss recent studies unraveling molecular mechanisms of excitatory/inhibitory synaptic transmission, long-term synaptic plasticity, and dentate granule cell excitability in the hippocampus of live animals. We focus on the role of three major postsynaptic proteins localized at excitatory (neuroligin-1) and inhibitory synapses (neuroligin-2 and collybistin). In vivo recordings of field potentials have the advantage of characterizing the effects of the loss of these proteins on the input-output function of granule cells embedded in a network with intact connectivity. The lack of neuroligin-1 leads to deficient synaptic plasticity and reduced excitation but normal granule cell output, suggesting unaltered excitation-inhibition ratio. In contrast, the lack of neuroligin-2 and collybistin reduces inhibition resulting in a shift towards excitation of the dentate circuitry.
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50647
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-506470
SN  - 2090-5904
SN  - 1687-5443
N1  - Copyright © 2018 Peter Jedlicka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 26
IS  - Art. 6015753
SP  - 1
EP  - 11
PB  - Hindawi
CY  - New York, NY
ER  -