TY  - JOUR
A1  - Mühl, Heiko
A1  - Bachmann, Malte
T1  - IL-18/IL-18BP and IL-22/IL-22BP : two interrelated couples with therapeutic potential
T2  - Cellular signalling
N2  - Interleukin (IL)-18 and IL-22 are key components of cytokine networks that play a decisive role in (pathological) inflammation, host defense, and tissue regeneration. Tight regulation of cytokine-driven signaling, inflammation, and immunoactivation is supposed to enable nullification of a given deleterious trigger without mediating overwhelming collateral tissue damage or even activating a cancerous face of regeneration. In fact, feedback regulation by specific cytokine opponents is regarded as a major means by which the immune system is kept in balance. Herein, we shine a light on the interplay between IL-18 and IL-22 and their opponents IL-18 binding protein (IL-18BP) and IL-22BP in order to provide integrated information on their biology, pathophysiological significance, and prospect as targets and/or instruments of therapeutic intervention.
KW  - Cytokines
KW  - Inflammation
KW  - Interleukin-18
KW  - Interleukin-18 binding protein
KW  - Interleukin-22
KW  - Interleukin-22 binding protein
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50819
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-508191
SN  - 1873-3913
SN  - 0898-6568
N1  - © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
VL  - 63
IS  - Art. 109388
SP  - 1
EP  - 14
PB  - Elsevier Science
CY  - Amsterdam [u. a.]
ER  -