TY  - JOUR
A1  - Goncharova, Olga
A1  - Flinner, Nadine
A1  - Bein, Julia
A1  - Döring, Claudia
A1  - Donnadieu, Emmanuel
A1  - Rikirsch, Sandy
A1  - Herling, Marco
A1  - Küppers, Ralf
A1  - Hansmann, Martin-Leo
A1  - Hartmann, Sylvia
T1  - Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cells
T2  - Cancers
N2  - Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advanced stage, cHL more frequently presents with localized disease. The aim of the present study was to elucidate the mechanisms underlying the different clinical presentation of ALCL and cHL. Chemokine and chemokine receptor expression were similar in primary ALCL and cHL cases apart from the known overexpression of the chemokines CCL17 and CCL22 in the Hodgkin and Reed-Sternberg (HRS) cells of cHL. Consistent with the overexpression of these chemokines, primary cHL cases encountered a significantly denser T cell microenvironment than ALCL. Additionally to differences in the interaction with their microenvironment, cHL cell lines presented a lower and less efficient intrinsic cell motility than ALCL cell lines, as assessed by time-lapse microscopy in a collagen gel and transwell migration assays. We thus propose that the combination of impaired basal cell motility and differences in the interaction with the microenvironment hamper the dissemination of HRS cells in cHL when compared with the tumor cells of ALCL.
KW  - anaplastic large cell lymphoma
KW  - dissemination
KW  - rosetting T cells
KW  - classical Hodgkin lymphoma
KW  - chemokine receptors
KW  - cell motility
KW  - segmentation
KW  - image analysis
KW  - gene expression
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51093
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-510931
SN  - 2072-6694
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 11
IS  - 10, Art. 1484
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  -