TY  - JOUR
A1  - Namgaladze, Dmitry
A1  - Khodzhaeva, Vera
A1  - Brüne, Bernhard
T1  - Er-mitochondria communication in cells of the innate immune system
T2  - Cells
N2  - In cells the interorganelle communication comprises vesicular and non-vesicular mechanisms. Non-vesicular material transfer predominantly takes place at regions of close organelle apposition termed membrane contact sites and is facilitated by a growing number of specialized proteins. Contacts of the endoplasmic reticulum (ER) and mitochondria are now recognized to be essential for diverse biological processes such as calcium homeostasis, phospholipid biosynthesis, apoptosis, and autophagy. In addition to these universal roles, ER-mitochondria communication serves also cell type-specific functions. In this review, we summarize the current knowledge on ER-mitochondria contacts in cells of the innate immune system, especially in macrophages. We discuss ER- mitochondria communication in the context of macrophage fatty acid metabolism linked to inflammatory and ER stress responses, its roles in apoptotic cell engulfment, activation of the inflammasome, and antiviral defense.
KW  - endoplasmic reticulum
KW  - mitochondria
KW  - macrophages
KW  - inflammation
KW  - lipid metabolism
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51995
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-519954
SN  - 2073-4409
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 8
IS  - 9, Art. 1088
SP  - 1
EP  - 21
PB  - MDPI
CY  - Basel
ER  -