TY  - JOUR
A1  - Gracien, René-Maxime
A1  - Petrov, Franca
A1  - Hok, Pavel
A1  - Wijnen, Alexandra van
A1  - Maiworm, Michelle
A1  - Seiler, Alexander
A1  - Deichmann, Ralf
A1  - Baudrexel, Simon
T1  - Multimodal quantitative mri reveals no evidence for tissue pathology in idiopathic cervical dystonia
T2  - Frontiers in neurology
N2  - Background: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathic dystonia revealed conflicting results.
Objective: Using multimodal qMRI, the presented study aimed to investigate alterations in different cerebral microstructural compartments associated with idiopathic cervical dystonia in vivo.
Methods: Mapping of T1, T2, T∗2, and proton density (PD) was performed in 17 patients with idiopathic cervical dystonia and 29 matched healthy control subjects. Statistical comparisons of the parametric maps between groups were conducted for various regions of interest (ROI), including major basal ganglia nuclei, the thalamus, white matter, and the cerebellum, and voxel-wise for the whole brain.
Results: Neither whole brain voxel-wise statistics nor ROI-based analyses revealed significant group differences for any qMRI parameter under investigation.
Conclusions: The negative findings of this qMRI study argue against the presence of overt microstructural tissue change in patients with idiopathic cervical dystonia. The results seem to support a common view that idiopathic cervical dystonia might primarily resemble a functional network disease.
KW  - idiopathic dystonia
KW  - quantitative MRI
KW  - relaxometry
KW  - proton density
KW  - movement disorders
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/52016
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-520163
SN  - 1664-2295
N1  - Copyright © 2019 Gracien, Petrov, Hok, van Wijnen, Maiworm, Seiler, Deichmann and Baudrexel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 10
IS  - Art. 914
SP  - 1
EP  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -