TY  - JOUR
A1  - Kuck, Karl-Heinz
A1  - Brugada, Josep
A1  - Schlüter, Michael
A1  - Braegelmann, Kendra M.
A1  - Kueffer, Fred J.
A1  - Chun, Kyoung-Ryul Julian
A1  - Albenque, Jean-Paul
A1  - Tondo, Claudio
A1  - Calkins, Hugh
T1  - The fire and ice trial: What we know, what we can still learn, and what we need to address in the future
T2  - Journal of the American Heart Association
N2  - The FIRE AND ICE Trial (ClinicalTrials.gov, identifier NCT01490814) was initiated in 2012 as a multicenter, randomized, head‐to‐head comparison of radiofrequency current (RFC) and cryoballoon catheter ablation for the treatment of patients with drug‐refractory symptomatic paroxysmal atrial fibrillation (AF). Six years on, it remains the largest, randomized comparison of safety and efficacy between 2 catheter ablation modalities used in the treatment of patients with AF. This landmark trial not only established noninferiority between cryoballoon and RFC ablation for pulmonary vein isolation (PVI) with regard to the study's efficacy and safety primary end points,1 but also, it evaluated secondary end points that were critical for a representative study interpretation. ...
KW  - catheter ablation
KW  - atrial fibrillation
KW  - radiofrequency
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54466
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-544663
SN  - 2047-9980
N1  - Copyright © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
VL  - 18
IS  - 24
SP  - 1
EP  - 10
PB  - Association
CY  - New York, NY
ER  -