TY  - JOUR
A1  - Raschle, Nora Maria
A1  - Fehlbaum, Lynn Valérie
A1  - Menks, Willeke M.
A1  - Martinelli, Anne
A1  - Prätzlich, Martin
A1  - Bernhard, Anka
A1  - Ackermann, Katharina
A1  - Freitag, Christine M.
A1  - De Brito, Stéphane A.
A1  - Fairchild, Graeme
A1  - Stadler, Christina
T1  - Atypical dorsolateral prefrontal activity in female adolescents with conduct disorder during effortful emotion regulation
T2  - Biological psychiatry. Cognitive neuroscience and neuroimaging
N2  - Background: Conduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional reactivity, emotion regulation, or both.
Methods: We used functional magnetic resonance imaging to study effortful emotion regulation by cognitive reappraisal in 59 female adolescents 15 to 18 years of age (30 with a CD diagnosis and 29 typically developing (TD) control adolescents).
Results: Behaviorally, in-scanner self-report ratings confirmed successful emotion regulation within each group individually but significant group differences in emotional reactivity and reappraisal success when comparing the groups (CD < TD). Functional magnetic resonance imaging results revealed significantly lower activation in left dorsolateral prefrontal cortex and angular gyrus in CD compared with TD adolescents during emotion regulation, but no group differences for emotional reactivity. Furthermore, connectivity between left dorsolateral prefrontal cortex and the bilateral putamen, right prefrontal cortex, and amygdala was reduced in CD compared with TD adolescents during reappraisal. Callous-unemotional traits were unrelated to neural activation, but these traits correlated negatively with behavioral reports of emotional reactivity.
Conclusions: Our results demonstrate reduced prefrontal brain activity and functional connectivity during effortful emotion regulation in female adolescents with CD. This sheds light on the neural basis of the behavioral deficits that have been reported previously. Future studies should investigate whether cognitive interventions are effective in enhancing emotion-regulation abilities and/or normalizing prefrontal and temporoparietal activity in female adolescents with CD.
KW  - Conduct disorder
KW  - Dorsolateral prefrontal cortex
KW  - Emotion processing
KW  - Emotion regulation
KW  - Female adolescents
KW  - fMRI
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54768
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-547681
SN  - 2451-9030
N1  - © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 4
IS  - 11
SP  - 984
EP  - 994
PB  - Elsevier Inc.
CY  - Amsterdam [u. a.]
ER  -