TY  - JOUR
A1  - Bosch-Lenders, Donna
A1  - Jansen, Jesse
A1  - Stoffers, Henri E. J. H.
A1  - Winkens, Bjorn
A1  - Aretz, Karin
A1  - Twellaar, Mascha
A1  - Schols, Jos M. G. A.
A1  - Kuy, Paul-Hugo Marie van der
A1  - Knottnerus, J. André
A1  - Akker, Marjan van den
T1  - The effect of a comprehensive, interdisciplinary medication review on quality of life and medication use in community dwelling older people with polypharmacy
T2  - Journal of Clinical Medicine
N2  - Background: We conducted a comprehensive medication review at the patients’ home, using data from electronic patient records, and with input from relevant specialists, general practitioners and pharmacists formulated and implemented recommendations to optimize medication use in patients aged 60+ years with polypharmacy. We evaluated the effect of this medication review on quality of life (QoL) and medication use. Methods: Cluster randomized controlled trial (stepped wedge), randomly assigning general practices to one of three consecutive steps. Patients received usual care until the intervention was implemented. Primary outcome was QoL (SF-36 and EQ-5D); secondary outcomes were medication changes, medication adherence and (instrumental) activities of daily living (ADL, iADL) which were measured at baseline, and around 6- and 12-months post intervention. Results: Twenty-four general practices included 360 women and 410 men with an average age of 75 years (SD 7.5). A positive effect on SF-36 mental health (estimated mean was stable in the intervention, but decreased in the control condition with −6.1, p = 0.009,) was found with a reduced number of medications at follow-up compared to the control condition. No significant effects were found on other QoL subscales, ADL, iADL or medication adherence. Conclusion: The medication review prevented decrease of mental health (SF36), with no significant effects on other outcome measures, apart from a reduction in the number of prescribed medications.
KW  - polypharmacy
KW  - primary care
KW  - medication review
KW  - cluster-randomized controlled trial
KW  - general practitioner
KW  - pharmacist
KW  - patient
KW  - home visit
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61774
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-617748
SN  - 2077-0383
VL  - 10
IS  - 4, art. 600
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  -