TY  - JOUR
A1  - Keresztes, Attila
A1  - Raffington, Laurel
A1  - Bender, Andrew R.
A1  - Bögl, Katharina
A1  - Heim, Christine
A1  - Shing, Yee Lee
T1  - Longitudinal developmental trajectories do not follow cross-sectional age associations in hippocampal subfield and memory development
T2  - Developmental cognitive neuroscience
N2  - Cross-sectional findings suggest that volumes of specific hippocampal subfields increase in middle childhood and early adolescence. In contrast, a small number of available longitudinal studies reported decreased volumes in most subfields over this age range. Further, it remains unknown whether structural changes in development are associated with corresponding gains in children’s memory. Here we report cross-sectional age differences in children’s hippocampal subfield volumes together with longitudinal developmental trajectories and their relationships with memory performance. In two waves, 109 participants aged 6–10 years (wave 1: MAge=7.25, wave 2: MAge=9.27) underwent high-resolution magnetic resonance imaging to assess hippocampal subfield volumes (imaging data available at both waves for 65 participants) and completed tasks assessing hippocampus dependent memory processes. We found that cross-sectional age-associations and longitudinal developmental trends in hippocampal subfield volumes were discrepant, both by subfields and in direction. Further, volumetric changes were largely unrelated to changes in memory, with the exception that increase in subiculum volume was associated with gains in spatial memory. Longitudinal and cross-sectional patterns of brain-cognition couplings were also discrepant. We discuss potential sources of these discrepancies. This study underscores that children’s structural brain development and its relationship to cognition cannot be inferred from cross-sectional age comparisons.
KW  - Mnemonic discrimination
KW  - Spatial memory
KW  - Associative memory
KW  - Pattern separation
KW  - Hippocampus
KW  - Subiculum
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63086
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-630860
SN  - 1878-9307
N1  - This study was supported by the Jacobs Foundation [grant 2014-1151 to YLS and CH] and conducted at the Center for Lifespan Psychology, Max Planck Institute for Human Development. The work of YLS was funded by a Minerva Research Group from the Max Planck Society, as well as from the European Union [ERC-2018-StG-PIVOTAL-758898], Jacobs Foundation [JRF 2018-2020], and Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, [Project-ID 327654276, SFB 1315], ”Mechanisms and Disturbances in Memory Consolidation: From Synapses to Systems”). A.K. was supported by the Hungarian National Research, Development and Innovation Office – NKFIH [FK 128648], and a Max Planck Partner Group from the Max Planck Society. K.B. was supported by the DFG (Project-ID 337619223/RTG 2386).
VL  - 54
IS  - art. 101085
SP  - 1
EP  - 14
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -