TY  - JOUR
A1  - Raimann, Florian
A1  - Lindner, Gesche Marie-Louise
A1  - Martin, Christoph
A1  - Jennewein, Lukas
A1  - Lustenberger, Thomas
A1  - Piekarski, Florian
A1  - Zacharowski, Kai
A1  - Weber, Christian Friedrich
T1  - Role of POC INR in the early stage of diagnosis of coagulopathy
T2  - Practical laboratory medicine
N2  - Background: Acute bleeding requires fast and targeted therapy. Therefore, knowledge of the patient's potential to form a clot is crucial. Point-of-care testing (POCT) provides fast and reliable information on coagulation. Structural circumstances, such as person-bound sample transport, can prolong the reporting of the results. The aim of the present study was to investigate the diagnostic quality and accuracy between POCT INR diagnostics and standard laboratory analysis (SLA) as well as the time advantage between a pneumatic tube and a personal-based transport system. Methods: Two groups of haemorrhagic patients (EG: emergency department; OG: delivery room; each n = 12) were examined in the context of bleeding emergencies using POCT and SLA. Samples were transported via a pneumatic tube system or by a personal transport service. Results: INR results between POCT and SLA showed a high and significant correlation (EG: p < 0.001; OG: p < 0.001). POCT results were reported significantly more quickly (EG: 1.1 vs. 39.6 min; OG: 2.0 vs. 75.0 min; p < 0.001) and required less time for analysis (EG: 0.3 vs. 24.0 min; OG: 0.5 vs. 45.0 min; p < 0.001) compared to SLA. The time for transportation with the pneumatic tube was significantly shorter (8.0 vs. 18.5 min; p < 0.001) than with the personal-based transport system. Conclusion: The results of the present study suggest that POCT may be a suitable method for the emergency diagnosis and may be used as prognostic diagnostic elements in haemotherapy algorithms to initiate targeted haemotherapy at an early point in time.
KW  - Point-of-care testing
KW  - International normalized ratio
KW  - INR
KW  - Bleeding
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63088
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-630887
SN  - 2352-5517
VL  - 26.2021
IS  - art. e00238
SP  - 1
EP  - 8
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -