TY  - JOUR
A1  - Rödel, Franz
A1  - Arenas, Meritxell
A1  - Ott, Oliver
A1  - Fournier, Claudia
A1  - Georgakilas, Alexandros G.
A1  - Tapio, Soile
A1  - Trott, Klaus-Rüdiger
A1  - Gaipl, Udo Sebastian
T1  - Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?
T2  - Strahlentherapie und Onkologie
N2  - In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
KW  - SARS-CoV-2
KW  - Low-dose radiation therapy
KW  - Pneumonia
KW  - COVID-19
KW  - Anti-inflammatory
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63778
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-637786
SN  - 1439-099X
N1  - Open Access funding provided by Projekt DEAL.
VL  - 196.2020
IS  - 8
SP  - 679
EP  - 682
PB  - Springer Medizin
CY  - Berlin ; Heidelberg
ER  -