TY  - JOUR
A1  - Stratmann, Katharina Christina
A1  - Czerwinska, Katarzyna
A1  - Filmann, Sonja Natalie
A1  - Tacke, Wolfgang
A1  - Weber, Christoph
A1  - Bock, Herbert
A1  - Blumenstein, Irina Ursula
T1  - Prevalence of colorectal cancer and its precursor lesions in symptomatic patients under 55 years of age undergoing total colonoscopy: results of a large retrospective, multicenter, controlled endoscopy study
T2  - International journal of colorectal disease
N2  - Purpose: Colorectal cancer (CRC) is the second most common cancer in Germany. Around 60,000 people were diagnosed CRC in 2016 in Germany. Since 2019, screening colonoscopies are offered in Germany for men by the age of 50 and for women by the age of 55. It is recently discussed if women should also undergo a screening colonoscopy by the age of 50 and if there are any predictors for getting CRC.
Methods: Colonoscopies of 1553 symptomatic patients younger than 55 years were compared with colonoscopies of 1075 symptomatic patients older than 55 years. We analyzed if there are any significant differences between those two groups in the prevalence of CRC and its precursor lesions or between symptomatic men and women. We evaluated if there is a correlation between abdominal symptoms and the prevalence of CRC.
Results: In 164/1553 symptomatic patients, 194 (12.5%) polyps were detected. In total, six colorectal carcinomas (0.4%) were detected. There were no significant differences between men and women. In symptomatic patients ≥ 55 years, significantly more polyps were found (p<0.0001; 26.6% vs. 12.5%). Totally, 286 polyps (26.6%) were removed in 1075 symptomatic patients older than 55 years. Anorectal bleeding was the only abdominal symptom being a significant indicator for the prevalence of the occurrence of colon and rectum cancer in both groups (p=0.03, OR=2.73 95%-CI [1.11;6.70]), but with only low sensitivity (44%).
Conclusion: Due to no significant differences in men and women, we recommend screening colonoscopies also for women by the age of 50.
KW  - Colorectal cancer
KW  - Lesions
KW  - Total colonoscopy
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63803
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-638035
SN  - 1432-1262
N1  - Open Access funding enabled and organized by Projekt DEAL.
N1  - Institut: Medizin
VL  - 36.2021
IS  - 8
SP  - 1695
EP  - 1700
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -