TY  - JOUR
A1  - Kim-Wanner, Soo-Zin
A1  - Luxembourg, Beate
A1  - Schmidt, Alexander H.
A1  - Schäfer, Richard
A1  - Möller, Nadine
A1  - Herbert, Eva
A1  - Poppe, Carolin
A1  - Hümmer, Christiane
A1  - Bunos, Milica
A1  - Seifried, Erhard
A1  - Bonig, Halvard-Björn
T1  - Introduction of principles of blood management to healthy donor bone marrow harvesting
T2  - Vox sanguinis
N2  - Background and Objectives: Patient blood (more accurately: haemoglobin, Hb) management (PBM) aims to optimize endogenous Hb production and to minimize iatrogenic Hb loss while maintaining patient safety and optimal effectiveness of medical interventions. PBM was adopted as policy for patients by the World Health Organization (WHO), and, all the more, should be applied to healthy donors. Materials and Methods: Observational data from 489 bone marrow (BM) donors were retrospectively analysed, and principles of patient blood management were applied to healthy volunteer BM donations. Results and Conclusion: We managed to render BM aspiration safe for donors, notably completely avoiding the collection of autologous blood units and blood transfusions through iron management, establishment and curation of high-yield aspiration technique, limitation of collection volume to 1·5% of donor body weight and development of volume prediction algorithms for the requested cell dose.
KW  - allogeneic donor
KW  - donor safety
KW  - patient blood management
KW  - stem cell transplantation
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63835
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-638354
SN  - 1423-0410
VL  - 115
IS  - 8
SP  - 802
EP  - 812
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -