TY - JOUR A1 - Friedauer, Lucie A1 - Rezny-Kasprzak, Beata A1 - Steinmetz, Helmuth A1 - Du Mesnil de Rochemont, Richard Klaus Frieder A1 - Förch, Christian T1 - Spinal dural leaks in patients with infratentorial superficial siderosis of the central nervous system - Refinement of a diagnostic algorithm T2 - European journal of neurology N2 - Background and purpose: Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric infratentorial siderosis pattern. Methods: In all, 97,733 magnetic resonance images performed between 2007 and 2018 in our neurocenter were screened by a keyword search for “hemosiderosis” and “superficial siderosis.” Siderosis patterns on brain imaging were classified according to a previously published algorithm. Potential causative intracranial bleeding events were also assessed. Patients with a symmetric infratentorial siderosis pattern but without causative intracranial bleeding events in history were prospectively evaluated for spinal pathologies. Results: Forty-two patients with isolated supratentorial siderosis, 30 with symmetric infratentorial siderosis and 21 with limited (non-symmetric) infratentorial siderosis were identified. Amyloid angiopathy and subarachnoid hemorrhage were causes for isolated supratentorial siderosis. In all four patients with a symmetric infratentorial siderosis pattern but without a causative intracranial bleeding event in history, spinal dural abnormalities were detected. Dural leaks were searched for in patients with symmetric infratentorial siderosis and a history of intracranial bleeding event without known bleeding etiology, considering that spinal dural CSF leaks themselves may also cause intracranial hemorrhage, for example by inducing venous thrombosis due to low CSF pressure. Thereby, one additional spinal dural leak was detected. Conclusions: Persisting spinal dural CSF leaks can frequently be identified in patients with a symmetric infratentorial siderosis pattern. Diagnostic workup in these cases should include magnetic resonance imaging of the whole spine. KW - cerebral hemorrhage KW - cerebral venous thrombosis KW - spinal dural leaks KW - superficial siderosis Y1 - 2020 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63861 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-638619 SN - 1468-1331 N1 - Early View: Online Version before inclusion in an issue. N1 - Open access funding enabled and organized by Projekt DEAL. N1 - Version of Record: http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hebis:30:3-639642 VL - 2020 IS - online version before inclusion in an issue PB - Wiley-Blackwell CY - Oxford [u.a.] ER -