TY  - JOUR
A1  - Jerkic, Silvija-Pera
A1  - Koç-Günel, Sinem
A1  - Herrmann, Eva
A1  - Kriszeleit, Lia
A1  - Eckrich, Jonas Martin
A1  - Schubert, Ralf
A1  - Zielen, Stefan
T1  - Long-term course of bronchial inflammation and pulmonary function testing in children with postinfectious bronchiolitis obliterans
T2  - Pediatric pulmonology
N2  - Rationale: Postinfectious bronchiolitis obliterans (PIBO) is a rare, chronic respiratory condition, which follows an acute insult due to a severe infection of the lower airways. Objectives: The objective of this study was to investigate the long-term course of bronchial inflammation and pulmonary function testing in children with PIBO. Methods: Medical charts of 21 children with PIBO were analyzed retrospectively at the Children's University Hospital Frankfurt/Main Germany. Pulmonary function tests (PFTs) with an interval of at least 1 month were studied between 2002 and 2019. A total of 382 PFTs were analyzed retrospectively and per year, the two best PFTs, in total 217, were evaluated. Additionally, 56 sputum analysis were assessed and the sputum neutrophils were evaluated. Results: The evaluation of the 217 PFTs showed a decrease in FEV1 with a loss of 1.07% and a loss in z score of −0.075 per year. FEV1/FVC decreased by 1.44 per year. FVC remained stable, showing a nonsignificant increase by 0.006 in z score per year. However, FEV1 and FVC in L increased significantly with FEV1 0.032 L per cm and FVC 0.048 L/cm in height. Sputum neutrophils showed a significant increase of 2.12% per year. Conclusion: Our results demonstrated that in patients with PIBO pulmonary function decreased significantly showing persistent obstruction over an average follow-up period of 8 years. However, persistent lung growth was revealed. In addition, pulmonary inflammation persisted clearly showing an increasing amount of neutrophils in induced sputum. Patients did not present with a general susceptibility to respiratory infections.
KW  - body plethysmography
KW  - chronic inflammation
KW  - lung function
KW  - postinfectious bronchiolitis obliterans
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63931
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-639317
SN  - 1099-0496
N1  - The authors wish to thank the foundation “Stiftung Starke Lunge” for the support. The “Stiftung Starke Lunge” is a nonprofitable foundation registered in Germany (Regierungspräsidium Darmstadt: AZ: I 1325d 04/11(6)−78) which supports research projects in pediatric rare lung diseases and specifically in BO.
VL  - 56
IS  - 9
SP  - 2966
EP  - 2972
PB  - Wiley-Liss
CY  - New York, NY [u.a.]
ER  -