TY  - JOUR
A1  - Aggensteiner, Pascal
A1  - Albrecht, Björn
A1  - Strehl, Ute
A1  - Wörz, Sonja
A1  - Ruckes, Christian Rainer
A1  - Freitag, Christine M.
A1  - Rothenberger, Aribert
A1  - Gevensleben, Holger
A1  - Millenet, Sabina
A1  - Hohmann, Sarah
A1  - Banaschewski, Tobias
A1  - Legenbauer, Tanja
A1  - Holtmann, Martin
A1  - Brandeis, Daniel
T1  - Can neurophysiological markers of anticipation and attention predict ADHD severity and neurofeedback outcomes?
T2  - Biological psychology
N2  - Abstract: Neurophysiological measures of preparation and attention are often atypical in ADHD. Still, replicated findings that these measures predict which patients improve after Neurofeedback (NF), reveal neurophysiological specificity, and reflect ADHD-severity are limited. Methods: We analyzed children’s preparatory (CNV) and attentional (Cue-P3) brain activity and behavioral performance during a cued Continuous Performance Task (CPT) before and after slow cortical potential (SCP)-NF or semi-active control treatment (electromyogram biofeedback). Mixed-effects models were performed with 103 participants at baseline and 77 were assessed for pre-post comparisons focusing on clinical outcome prediction, specific neurophysiological effects of NF, and associations with ADHD-severity. Results: Attentional and preparatory brain activity and performance were non-specifically reduced after treatment. Preparatory activity in the SCP-NF group increased with clinical improvement. Several performance and brain activity measures predicted non-specific treatment outcome. Conclusion: Specific neurophysiological effects after SCP-NF were limited to increased neural preparation associated with improvement on ADHD-subscales, but several performance and neurophysiological measures of attention predicted treatment outcome and reflected symptom severity in ADHD. The results may help to optimize treatment.
KW  - Neurofeedback
KW  - Slow Cortical Potentials, SCP
KW  - Randomized Controlled Trial
KW  - Attention-Deficit/Hyperactivity Disorder (ADHD)
KW  - Sustained attention
KW  - Response control
KW  - Continuous Performance Test, CPT
KW  - Contingent Negative Variation, CNV
KW  - Cue-P3
KW  - Event related potentials
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64426
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-644263
SN  - 1873-6246
N1  - This study was funded by the German Research Foundation DFG HO 2503/4-1 and 2503/4-2. The funding body had no influence on the study design, collection, analysis and interpretation of data, the writing of the report, or the decision to submit the paper for publication.
VL  - 165
IS  - art. 108169
SP  - 1
EP  - 12
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  -