TY  - CONF
A1  - Tunjung, Woro Anindito Sri
A1  - Cinatl, Jindrich
A1  - Michaelis, Martin
A1  - Smales, Christopher Mark
T1  - Anti-cancer effect of kaffir lime (Citrus Hystrix DC) leaf extract in cervical cancer and neuroblastoma cell lines
T2  - Procedia Chemistry
N2  - Previous study showed that kaffir lime leaf contains alkaloid, flavonoid, terpenoid, tannin and saponin. The objective of this study was to examine the cytotoxic effect of kaffir lime leaf extract on cervical cancer and neuroblastoma cell lines. The method used for this research to determine cell viability was an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results showed that an ethyl acetate extract had an IC50 for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental cells of 40.7 μg · mL–1, 28.4 μg · mL–1, 14.1 μg · mL–1, and 25.2 μg · mL–1 respectively. Furthermore, the IC50 of chloroform extracts for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental were 17.6 μg · mL–1, 18.9 μg · mL–1, 6.4 μg · mL–1, and 9.4 μg · mL–1 respectively. These data showed that kaffir lime extract reduces the viability of cervical and neuroblastoma cell lines and may have potential as anti-cancer compounds.
KW  - cervical cancer
KW  - kaffir lime
KW  - MTT assay
KW  - neuroblastoma
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75951
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-759517
SN  - 1876-6196
VL  - 14
SP  - 465
EP  - 468
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -