Sulforaphane impact on reactive oxygen species (ROS) in bladder carcinoma
- Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
Download full text files
Additional Services
| Author: | Hui Xie, Felix ChunORCiDGND, Jochen RutzGND, Roman A. BlahetaORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-624882 |
| DOI: | https://doi.org/10.3390/ijms22115938 |
| ISSN: | 1422-0067 |
| Parent Title (English): | International journal of molecular sciences |
| Publisher: | Molecular Diversity Preservation International |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/05/31 |
| Date of first Publication: | 2021/05/31 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2021/09/08 |
| Tag: | Keap1-Nrf2; ROS; bladder cancer; oxidative stress; sulforaphane |
| Volume: | 22 |
| Issue: | 11, art. 5938 |
| Page Number: | 19 |
| First Page: | 1 |
| Last Page: | 19 |
| Note: | This work was supported by the Brigitta & Norbert Muth Stiftung, Wiesbaden, Germany, and the China Scholarship Council No. 201707660003. |
| HeBIS-PPN: | 48757687X |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Open-Access-Publikationsfonds: | Medizin |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
