Christoph Stephan Clemen, Marija Marko, Karl-Heinz Strucksberg, Juliane Behrens, Ilka Wittig, Linda Gärtner, Lilli Winter, Frederic Chevessier, Jan Matthias, Matthias Türk, Karthikeyan Tangavelou, Johanna Schütz, Khalid Arhzaouy, Karsten Klopffleisch, Franz-Georg Hanisch, Wolfgang Rottbauer, Ingmar Blümcke, Steffen Just, Ludwig Eichinger, Andreas Hofmann, Rolf Schröder
- Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity.
Metadaten| Author: | Christoph Stephan ClemenORCiDGND, Marija Marko, Karl-Heinz Strucksberg, Juliane Behrens, Ilka WittigORCiD, Linda Gärtner, Lilli WinterORCiD, Frederic Chevessier, Jan Matthias, Matthias Türk, Karthikeyan Tangavelou, Johanna Schütz, Khalid Arhzaouy, Karsten Klopffleisch, Franz-Georg Hanisch, Wolfgang Rottbauer, Ingmar Blümcke, Steffen Just, Ludwig EichingerORCiDGND, Andreas Hofmann, Rolf Schröder |
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| URN: | urn:nbn:de:hebis:30:3-393822 |
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| DOI: | https://doi.org/10.1016/j.bbrc.2015.06.086 |
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| ISSN: | 0006-291X |
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| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/26086101 |
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| Parent Title (English): | Biochemical and biophysical research communications |
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| Publisher: | Elsevier |
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| Place of publication: | San Diego, Calif. |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2015/08/07 |
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| Date of first Publication: | 2015/06/15 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2016/05/30 |
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| Volume: | 463 |
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| Page Number: | 8 |
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| First Page: | 1210 |
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| Last Page: | 1217 |
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| Note: | © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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| HeBIS-PPN: | 427808464 |
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| Institutes: | Medizin / Medizin |
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| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0