Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
- The new variant of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype strain (B.1) with respect to their interactions with the antiviral type I interferon (IFN-alpha/beta) response in infected cells. Our data indicate that Omicron has gained an elevated capability to suppress IFN-beta induction upon infection and to better withstand the antiviral state imposed by exogenously added IFN-alpha.
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| Author: | Lyudmila ShalamovaORCiDGND, Ulrike FelgenhauerORCiDGND, Andreas R. SchaubmarORCiDGND, Kathrin BüttnerGND, Marek WideraORCiDGND, Sandra CiesekORCiDGND, Friedemann WeberORCiDGND |
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| URN: | urn:nbn:de:hebis:30:3-730019 |
| DOI: | https://doi.org/10.1101/2022.01.20.476754 |
| Parent Title (English): | bioRxiv |
| Document Type: | Preprint |
| Language: | English |
| Date of Publication (online): | 2022/01/20 |
| Date of first Publication: | 2022/01/20 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/03/21 |
| Issue: | 2022.01.20.476754 |
| Page Number: | 10 |
| HeBIS-PPN: | 506717186 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
