Adaptive modeling of biochemical pathways
- In bioinformatics, biochemical pathways can be modeled by many differential equations. It is still an open problem how to fit the huge amount of parameters of the equations to the available data. Here, the approach of systematically learning the parameters is necessary. In this paper, for the small, important example of inflammation modeling a network is constructed and different learning algorithms are proposed. It turned out that due to the nonlinear dynamics evolutionary approaches are necessary to fit the parameters for sparse, given data. Keywords: model parameter adaption, septic shock. coupled differential equations, genetic algorithm.
| Author: | Rüdiger W. BrauseGND |
|---|---|
| URN: | urn:nbn:de:hebis:30-79299 |
| Parent Title (German): | International Journal on Artificial Intelligence Tools |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2010/09/08 |
| Year of first Publication: | 2004 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2010/09/08 |
| Tag: | coupled differential equations; genetic algorithm; model parameter adaption; septic shock |
| Volume: | 13 |
| First Page: | 851 |
| Last Page: | 862 |
| Source: | International Journal on Artificial Intelligence Tools, 13, S. 851-862 |
| HeBIS-PPN: | 228107857 |
| Institutes: | Informatik und Mathematik / Informatik |
| Dewey Decimal Classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Deutsches Urheberrecht |
