Cell stress and cell death

  • Editorial: This special issue on Cell Stress and Cell Death is aimed at bringing together recent developments in the fields of cellular stress and cell death and, in particular, the interplay between cell stress responses and cell death. The special issue opens with a review by S. Fulda et al. which provides an overview of how cells can respond to stress in a variety of ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective response or succumb to death depends to a large extent on the nature and duration of the stress as well as the cell type. For example, milder stresses can lead to protection through activation of the heat shock response or the unfolded protein response (UPR). This review also describes several types of cell death (e.g., apoptosis, necrosis, pyroptosis, or autophagic cell death) and the mechanism by which a cell dies often depends on various exogenous factors as well as the cell’s ability to handle the stress to which it is exposed. The implications of cellular stress responses for human physiology and disease are multifold and are discussed in this review in the context of some major world health issues such as diabetes, Parkinson’s disease, myocardial infarction, and cancer. ...

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Metadaten
Author:Afshin Samali, Simone FuldaORCiDGND, Adrienne M. Gorman, Osamu Hori, Srinivasa M. Srinivasula
URN:urn:nbn:de:hebis:30:3-242788
DOI:https://doi.org/10.1155/2010/245803
ISSN:1687-8884
ISSN:1687-8876
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/20339528
Parent Title (English):International journal of cell biology
Publisher:Hindawi
Place of publication:New York, NY
Document Type:Article
Language:English
Year of Completion:2012
Year of first Publication:2010
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/05/23
Volume:2010
Issue:Article ID 245803
Page Number:2
HeBIS-PPN:303614730
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0