Personalizing HIV therapy, mission impossible?

  • Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings. Treatment response rates range up to 90% in therapy naïve patients but decline to approximately 50% in patients who received several antiretrovirals during treatment history. Furthermore, HIV protease inhibitors (PI) and non nucleoside reverse transcriptase inhibitors (NNRTI) plasma concentrations display high inter- and intra individual variability and the therapeutic window is comparably narrow. In this therapeutic setting the personalization of dosing regimens has been suggested in many cases to tailor the ARV plasma concentrations with the intention to maximize therapy success and minimize side effects in the individual. However, personalizing therapy by modifying the dosing regimen bears the danger of losing therapeutic efficacy, increasing side effects or causing viral resistance. This topical review identifies pharmacokinetic and pharmacodynamic models of antiretroviral therapy appraising the potential application to HIV therapy and discusses its future in the light of new drug classes and fix-dose combinations.

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Author:Nils von HentigORCiDGND
Parent Title (English):Journal of antivirals and aintiretrovirals
Publisher:OMICS Publishing Group
Place of publication:[S.l.]
Document Type:Article
Date of Publication (online):2013/01/30
Date of first Publication:2013/01/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/10/01
Tag:Antiretrovirals; HIV therapy; Pharmacodynamic
Page Number:9
First Page:12
Last Page:20
Copyright: © 2013 Hentig NV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0