Survival according to BRAF-V600 tumor mutations : an analysis of 437 patients with primary melanoma

  • The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437 patients diagnosed between 1989 and 2006 by Sanger sequencing. Mutations were detected in 38.7% of patients and were associated with age, histological subtype as well as mitotic rate. The mutational rate was 36.7% in patients with disease-free course and 51.7% in those with subsequent distant metastasis (p = 0.031). No difference in overall survival (p = 0.119) but a trend for worse distant-metastasis-free survival (p = 0.061) was observed in BRAF mutant compared to BRAF wild-type patients. Independent prognostic factors for overall survival were tumor thickness, mitotic rate and ulceration. An interesting significant prognostic impact was observed in patients with tumor thickness of 1 mm or less, with the mutation present in 6 of 7 patients dying from melanoma. In conclusion, no significant survival differences were found according to BRAF-V600 tumor mutations in patients with primary melanoma but an increasing impact of the mutational status was observed in the subgroup of patients with tumor thickness of 1 mm or less. A potential role of the mutational status as a prognostic factor especially in this subgroup needs to be investigated in larger studies.

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Author:Diana Meckbach, Jürgen Bauer, Annette Pflugfelder, Friedegund MeierGND, Christian Busch, Thomas Kurt Eigentler, David Capper, Andreas von Deimling, Michel Guy André Mittelbronn, Sven Perner, Kristian Ikenberg, Markus Hantschke, Petra Büttner, Claus Garbe, Benjamin Weide
URN:urn:nbn:de:hebis:30:3-327957
DOI:https://doi.org/10.1371/journal.pone.0086194
ISSN:1932-6203
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24475086
Parent Title (English):PLoS One
Publisher:PLoS
Place of publication:Lawrence, Kan.
Document Type:Article
Language:English
Date of Publication (online):2014/01/24
Date of first Publication:2014/01/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2014/01/27
Volume:9
Issue:(1):e86194
Page Number:10
Note:
Copyright: © 2014 Meckbach et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HeBIS-PPN:363413448
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0