Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues

  • In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.

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Author:Abdelaaziz Ouahrouch, Moha Taourirte, Joachim W. Engels, Soumaya Benjelloun, Hassan B. Lazrek
URN:urn:nbn:de:hebis:30:3-343083
DOI:https://doi.org/10.3390/molecules19033638
ISSN:1420-3049
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24662079
Parent Title (English):Molecules
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2014/11/22
Date of first Publication:2014/03/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2014/11/22
Tag:1,2,3-triazole-acyclonucleosides; HCV; Huisgen cycloaddition; quinazoline ribonucleosides; quinazolinone alkylation
Volume:19
Issue:3
Page Number:16
First Page:3638
Last Page:3653
Note:
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
HeBIS-PPN:366536400
Institutes:Biochemie, Chemie und Pharmazie / Biochemie und Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0