Recording of brain activity across spatial scales

  • Brain activity reveals exquisite coordination across spatial scales, from local microcircuits to brain-wide networks. Understanding how the brain represents, transforms and communicates information requires simultaneous recordings from distributed nodes of whole brain networks with single-cell resolution. Realizing multi-site recordings from communicating populations is hampered by the need to isolate clusters of interacting cells, often on a day-to-day basis. Chronic implantation of multi-electrode arrays allows long-term tracking of activity. Lithography on thin films provides a means to produce arrays of variable resolution, a high degree of flexibility, and minimal tissue displacement. Sequential application of surface arrays to monitor activity across brain-wide networks and subsequent implantation of laminar arrays to target specific populations enables continual refinement of spatial scale while maintaining coverage.

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Author:Christopher Murphy LewisORCiD, Conrado A. BosmanORCiD, Pascal FriesORCiDGND
Pubmed Id:
Parent Title (English):Current Opinion in Neurobiology
Publisher:Current Biology
Place of publication:Philadelphia, Pa
Document Type:Article
Date of Publication (online):2014/12/24
Date of first Publication:2014/12/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/06/14
Page Number:10
First Page:68
Last Page:77
© 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-SA license (
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Keine kommerzielle Nutzung-Weitergabe unter gleichen Bedingungen