Systematic classification of mixed-lineage leukemia fusion partners predicts additional cancer pathways
- Chromosomal translocations of the human mixed-lineage leukemia (MLL) gene have been analyzed for more than 20 yr at the molecular level. So far, we have collected about 80 direct MLL fusions (MLL-X alleles) and about 120 reciprocal MLL fusions (X-MLL alleles). The reason for the higher amount of reciprocal MLL fusions is that the excess is caused by 3-way translocations with known direct fusion partners. This review is aiming to propose a solution for an obvious problem, namely why so many and completely different MLL fusion alleles are always leading to the same leukemia phenotypes (ALL, AML, or MLL). This review is aiming to explain the molecular consequences of MLL translocations, and secondly, the contribution of the different fusion partners. A new hypothesis will be posed that can be used for future research, aiming to find new avenues for the treatment of this particular leukemia entity.
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| Author: | Rolf MarschalekORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-306466 |
| DOI: | https://doi.org/10.3343/alm.2016.36.2.85. |
| ISSN: | 2234-3814 |
| ISSN: | 2234-3806 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/26709255 |
| Parent Title (German): | Annals of laboratory medicine |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2016 |
| Year of first Publication: | 2016 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2017/01/11 |
| Tag: | MLL-r leukemia; Molecular mechanisms of cancer; Translocation partner genes |
| Volume: | 36 |
| Page Number: | 16 |
| First Page: | 85 |
| Last Page: | 100 |
| Note: | © The Korean Society for Laboratory Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| HeBIS-PPN: | 427807433 |
| Institutes: | Biochemie, Chemie und Pharmazie / Pharmazie |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell 3.0 |
