Mitochondrial composition and function under the control of hypoxia

  • Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.

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Author:Dominik Christian FuhrmannORCiDGND, Bernhard BrüneORCiD
URN:urn:nbn:de:hebis:30:3-430171
DOI:https://doi.org/10.1016/j.redox.2017.02.012
ISSN:2213-2317
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/28259101
Parent Title (English):Redox Biology
Publisher:Elsevier
Place of publication:Amsterdam [u. a.]
Document Type:Article
Language:English
Date of Publication (online):2017/03/09
Date of first Publication:2017/02/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2017/03/09
Tag:HIF; Hypoxia; Mitochondria; ROS; Respiratory chain
Volume:12
Page Number:8
First Page:208
Last Page:215
Note:
© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Institutes:Medizin / Medizin
Wissenschaftliche Zentren und koordinierte Programme / Sonderforschungsbereiche / Forschungskollegs
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0