Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
- The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice.
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| Author: | Flávia Figueiredo de Rezende FelipeORCiDGND, Christoph SchürmannORCiDGND, Susanne Schütz, Sabine Harenkamp, Eva HerrmannORCiDGND, Michael Seimetz, Norbert WeißmannGND, Katrin SchröderORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-432422 |
| DOI: | https://doi.org/10.1016/j.redox.2016.12.012 |
| ISSN: | 2213-2317 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28038425 |
| Parent Title (English): | Redox Biology |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam [u. a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2017/06/26 |
| Year of first Publication: | 2016 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2017/06/26 |
| Tag: | Aging; Nox4 |
| Volume: | 11 |
| Page Number: | 3 |
| First Page: | 312 |
| Last Page: | 314 |
| Note: | © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). |
| HeBIS-PPN: | 425339270 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
