Diagnostic and treatment modalities for patients with cervical lymph node metastases of unknown primary site - current status and challenges
- Background and Purpose: This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown primary (CUP). Methods: A literature search for head and neck CUP was performed with focus on diagnostics and therapies as well as molecular markers. Results: High level evidence on CUP is limited. However, it seems that a consensus exists regarding the optimal diagnostic procedures. The correct implementation of biomarkers for patient stratification and treatment remains unclear. An even greater dispute dominates about the ideal treatment with publications ranging from sole surgery to surgery with postoperative bilateral radiotherapy with inclusion of the mucosa and concomitant chemotherapy. Conclusions: Cervical CUP represents a very heterogeneous malignant disease. On this account many aspects concerning treatment optimization remain unclear, despite a considerable number of publications in the past. Future research in form of prospective randomized trials is needed in order to better define patient stratification criteria and enable tailored treatment.
Download full text files
Additional Services
| Author: | Jens Müller-von der GrünORCiDGND, Aykut Tahtali, Shahram Michael GhanaatiORCiDGND, Claus RödelORCiDGND, Panagiotis BalermpasORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-441076 |
| DOI: | https://doi.org/10.1186/s13014-017-0817-9 |
| ISSN: | 1748-717X |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28486947 |
| Parent Title (English): | Radiation oncology |
| Publisher: | BioMed Central |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2017/05/15 |
| Date of first Publication: | 2017/05/10 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2017/05/15 |
| Tag: | CUP; Cancer of unknown primary; Cervical; Head and neck cancer; Lymph node |
| Volume: | 12 |
| Issue: | 1, Art. 82 |
| Page Number: | 12 |
| First Page: | 1 |
| Last Page: | 12 |
| Note: | Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| HeBIS-PPN: | 425337448 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
