Suicidal hanging donors for lung transplantation : is this chapter still closed? midterm experience from a single center in United Kingdom

  • In the context of limited donor pool in cardiothoracic transplantation, utilization of organs from high risk donors, such as suicidal hanging donors, while ensuring safety, is under consideration. We sought to evaluate the outcomes of lung transplantations (LTx) that use organs from this group. Between January 2011 and December 2015, 265 LTx were performed at our center. Twenty-two recipients received lungs from donors after suicidal hanging (group 1). The remaining 243 transplantations were used as a control (group 2). Analysis of recipient and donor characteristics as well as outcomes was performed. No statistically significant difference was found in the donor characteristics between analyzed groups, except for higher incidence of cardiac arrest, younger age and smoking history of hanging donors (P < .001, P = .022 and P = .0042, respectively). Recipient preoperative and perioperative characteristics were comparable. Postoperatively in group 1 there was a higher incidence of extracorporeal life support (27.3 vs 9.1%, P = .019). There were no significant differences in chronic lung allograft dysfunction-free survival between group 1 and 2: 92.3 vs 94% at 1 year and 65.9 vs 75.5% at 3 years (P = .99). The estimated cumulative survival rate was also similar between groups: 68.2 vs 83.2% at 1 year and 68.2% versus 72% at 3 years (P = .3758). Hanging as a donor cause of death is not associated with poor mid-term survival or chronic lung allograft dysfunction following transplantation. These results encourage assessment of lungs from hanging donors, and their consideration for transplantation.
Author:Olga Ananiadou, Bastian SchmackGND, Bartlomiej Zych, Anton Sabashnikov, Diana Garcia-Saez, Prashant Mohite, Alexander WeymannGND, Ashham Mansur, Mohamed Zeriouh, Nandor Marczin, Fabio De Robertis, André R. Simon, Aron-Frederik Popov
Pubmed Id:
Parent Title (English):Medicine
Publisher:Lippincott Williams & Wilkins
Place of publication:Baltimore, Md.
Contributor(s):Danny Chu
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/04/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/04/19
Tag:hanging donors; lung transplantation; outcomes
Page Number:6
First Page:1
Last Page:6
Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NCND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0